Pain Profiles

Discovering Molecules Associated with Pain

The pain market is $27 billion in the USA and $50 billion worldwide. According to the Institute of Medicine of the National Academies, chronic pain affects 100 million Americans and costs the nation up to $635 billion annually.  

Number of American Affected by Pain.

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Types of Pain Disease Number of Americans Affected References
Acute Pain Injury 29.5 million

National Hospital Ambulatory Medical Care Survey: 2009 Emergency Department Summary Tables. Ambulatory Health Care Data 2009

Rui P, Kang K, Albert M. National Hospital Ambulatory Medical Care

Survey: 2013 Emergency Department Summary Tables

Surgery 72 million Owings, M.F. and L.J. Kozak, Ambulatory and inpatient procedures in the United States, 1996. Vital and health statistics. Series 13, Data from the National Health Survey, 1998(139): p. 1-119
Chronic Pain – Nociceptive Osteoarthritis 26.9 million

Rodriguez-Amado, J., et al., Epidemiology of rheumatic diseases. A community-based study in urban and rural populations in the state of Nuevo Leon, Mexico. The Journal of rheumatology. Supplement, 2011. 86: p. 9-14.

Yoshimura, N., [Epidemiology of osteoarthritis in Japan : the ROAD study]. Clinical calcium, 2011. 21(6): p. 821-5

Flugsrud, G.B., et al., [Osteoarthritis]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2010. 130(21): p. 2136-40.

Sarzi-Puttini, P., et al., Osteoarthritis: an overview of the disease and its treatment strategies. Seminars in arthritis and rheumatism, 2005. 35(1 Suppl 1): p. 1-10.

Walsh, D.A. and D.F. McWilliams, Pain in rheumatoid arthritis. Current pain and headache reports, 2012. 16(6): p. 509-17

Rheumatoid Arthritis 1.5 million

Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States- Part I. Arthritis & Rheum. 2008: 58(1):15-25.

Rodriguez-Amado, J., et al., Epidemiology of rheumatic diseases. A community-based study in urban and rural populations in the state of Nuevo Leon, Mexico. The Journal of rheumatology. Supplement, 2011. 86: p. 9-14

Chronic Pain – Neuropathic Stroke 795,000

CDC. Prevalence of stroke — United States, 2006–2010. MMWR 2012;61:379–82.

Mozaffarian, D., et al., Heart Disease and Stroke Statistics—2015 Update. A Report From the American Heart Association, 2015. 131(4): p. e29-e322

Mozaffarian, D., et al., Heart Disease and Stroke Statistics—2016 Update. A Report From the American Heart Association, 2015[/note]

Multiple Sclerosis 400,000 Dilokthornsakul, Piyameth et al. “Multiple Sclerosis Prevalence in the United States Commercially Insured Population.” Neurology 86.11 (2016): 1014–1021. PMC. Web. 9 May 2017
Spinal Cord Injury 232,000 Singh, A., Tetreault, L., Kalsi-Ryan, S., Nouri, A., & Fehlings, M. G. (2014). Global prevalence and incidence of traumatic spinal cord injury. Clinical Epidemiology, 6, 309–331. http://doi.org/10.2147/CLEP.S68889
Sciatica 1.3 million
Migraine 17.7 million

Lipton, R.B., et al., Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache, 2001. 41(7): p. 646-57

Burch, R.C., et al., The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache, 2015. 55(1): p. 21-34

Smitherman, T. A., Burch, R., Sheikh, H. and Loder, E. (2013), The Prevalence, Impact, and Treatment of Migraine and Severe Headaches in the United States: A Review of Statistics From National Surveillance Studies. Headache: The Journal of Head and Face Pain, 53: 427–436. doi:10.1111/head.12074

Supiot, F., [Migraine in 2009: from attack to treatment]. Revue medicale de Bruxelles, 2009. 30(4): p. 399-403.

Bener, A., Frequency of headache and migraine in Qatar. Neuroepidemiology, 2006. 27(2): p. 61-6.

Klingler, D. and B. Bauchinger, [Migraine–summary of diagnostic and therapeutic strategies]. Wiener medizinische Wochenschrift, 1994. 144(5-6): p. 117-20

HIV-related Neuropathy 383,066
Postherpetic Neuralgia 100,000 Argoff, C.E., Review of current guidelines on the care of postherpetic neuralgia. Postgraduate medicine, 2011. 123(5): p. 134-42
Diabetic Neuropathy 8.6 million O’Hare, J.A., F. Abuaisha, and M. Geoghegan, Prevalence and forms of neuropathic morbidity in 800 diabetics. Irish journal of medical science, 1994. 163(3): p. 132-5
Chronic Pain – Visceral Pancreatitis 210,000
Heart Attack 920,000
Hereditary Angioedema 6174 Longhurst, H. and M. Cicardi, Hereditary angio-oedema. The Lancet. 379(9814): p. 474-481
Inflammatory Bowel Syndrome 1.4 million
Chronic Pain – Mixed Lower Back 84 million Pleis, J.R., B.W. Ward, and J.W. Lucas, Summary health statistics for U.S. adults: National Health Interview Survey, 2009 (provisional report). Vital Health Stat, 2010. 10: p. 249
Cancer 6.3 million SEER Cancer Statistics Review, 1975-2009. 2011, National Cancer Institute
Complex Regional Pain Syndrome 62,318
Fibromyalgia 5 million Lawrence, R.C., et al., Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis and rheumatism, 2008. 58(1): p. 26-35
Temporomandibular Joint Disorder 62,318

Statistics obtained from the Centers of Disease Control and Prevention and estimated from selected publications

This test is intended to be used by scientists for research purposes only.

This work was supported by the US Army Medical Research and Materiel Command under Contract No. W81XWH-13-C-0091. The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.