Pain Test

There are no IP issues with our service.  You own all your data.  If we use other services, we make sure there are no IP issues.

Data Collection

During our studies, we found that pain is much more complicated than expected and we are trying to develop new tools to better understand pain.  To help identify different sources of pain. we developed a database of painful diseases and conditions (PainIndex). 

 We can collect clinical information for any study.  For  easy data entry, we have a pain information app that can be modified to collect any additional information.  The data can be exported in a spreadsheet that can be used in several different programs.

We look at clinical information for biomarker discovery.  This can be different than the way a clinician looks at information when treating a patient.  In the beginning, it is important to capture all clinical data needed for biomarker discovery and validation.  Pain is complex and it is difficult to know in advance all the things that might affect biomarker levels.

Complexity of Patient Samples

Plot of individual samples vs number of diagnostic codes

Real world samples can be very complex.

The number of diagnostic codes can vary greatly between different sites.

Microarray Analysis

Candidate biomarkers were found using high resolution mass spectrometry.  We obtained promising results with our microarrays.  However, our pain test is at the research stage.  Since there are few biomarkers available, we can offer the test for research purposes.

Custom Arrays

Biomarker Profiles maintains a biomarker database.  We use the database to add candidate biomarkers to our custom arrays.

Biomarker Profiling

 We can use any commercially available microarray.

Population Profiling

We profile disease using clinical information and biomarkers.  We can provide this as a service for a few runs so we can modify the app for your data. No extra charge for the modifications.

Data is imported into a database and can be exported into a spreadsheet for easy sharing.

Data Analysis

We use business intelligence software to visualize the analysis.  After statistical analysis, we perfom another round of visualization.

We profile disease using clinical information and biomarkers.

When studying pain, we sometimes find other clinical variables that can affect test results.  

Patients with more than one disease/condition report higher pain

Individual samples (sorted by pain score) vs diseases/conditions

Sample collections can contain recent injuries

Individual samples (sorted by pain score) vs injury counts

Sample collections can contain cancer

Individual samples (sorted by pain score) vs cancer counts

This test is intended to be used by scientists for research purposes only.

This work was supported by the US Army Medical Research and Materiel Command under Contract No. W81XWH-13-C-0091. The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

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